Cell & Tissue Engineering

cell and tissue engineeringOne of the most exciting areas in biomedical engineering is tissue engineering. Tissue engineering is the ability to generate living tissue ex vivo for replacement or therapeutic applications through materials development, biochemical manipulations, cell culture, and genetic engineering.

This area of research and development has the potential to revolutionize the treatment of a wide variety of disorders and injuries.

Of fundamental importance in the design of such tissues is the ability to understand and predict how cell behavior, cell growth, and differentiation are affected by the mechanochemistry of the cellular environment. There is ample evidence showing that the physical surroundings of cells, both chemical and mechanical, can have profound effects on cellular behavior, including growth and differentiation.

Of particular importance is first understanding, then controlling, the effects of physical contacts between cells, between cells and artificial substrates, and between cells and the extracellular matrix that they produce.

Molecular, cellular and tissue engineering encompasses the study of cellular interactions using principles of engineering, physical chemistry, and physics to more clearly understand the mechanism of cellular responses to surface contacts. It includes the design of surfaces for the purpose of eliciting a particular cellular response, and it includes the application of this knowledge to generate cellular systems for therapeutics, sensors, and novel tools for research.

Example Research Projects:

cellandtissue1 cellandtissue2 cellandtissue3 cellandtissue4 cellandtissue5 biological effects of ultrasound cell cytoplasm
basic biology biomaterials skeleton bone repair cell based regeneration contrast agents drug delivery dynamic bond formation
dynamic response electroprocessing flexor tendon fracture healing hydrogel culture ICAM local delivery
mechanical force micro-fluidics microbubble arrays models of skeletal disease multi-scaled computational analysis nano-structured bioreactors nanoparticles therapeutics
novel agents red blood cells regenerative medicine responses fibronectin tissue engineering allograft ultrasound technology venular wall
wound healing microbubble stem cells organ of corti polymer drugs porous biosensors skin dendritic therapeutic ultrasound
massive bone

Current Researchers:

Hani A. Awad, PhD Musculoskeletal tissue engineering
Danielle Benoit, PhD Therapeutic biomaterials
Mark Buckley, PhD Viscoelasticity in soft biological tissues; soft tissue aging, disease and repair
Patricia Chess, PhD Effects of strain on pulmonary epithelium
Robert L. Clark, PhD Dynamic systems, measurement and control, and the exploration of single-molecule mechanics
Diane Dalecki, PhD Biomedical ultrasound, acoustics, lithotripsy, biological effects of ultrasound
David Dean, PhD Gene therapy
Lisa A. DeLouise, PhD, MPD Engineering smart bandage bio nanomaterials for healing skin
Angela Glading, PhD Role of cell-cell contact in regulating cellular function in both the normal and disease state
Denise C. Hocking, PhD Regulation of cell behavior by the extracellular matrix
Catherine K. Kuo, PhD Tissue engineering; Orthopaedics; Stem cells; Developmental biology; Mechanobiology; Biomaterials
Elena Lomakina, PhD Cell adhesion, mechanical and thermodynamic properties of biological membranes; cellular mechanics and function of cytoskeletal proteins
Anne Luebke, PhD Role of cochlear outer hair cells in hearing and hearing loss, at both the molecular and systems levels
James L. McGrath, PhD Cell motility, and quantitative light microscopy
Jong-Hoon Nam, PhD Biophysics of inner ear sensory cells, cell mechanics
J. Edward Puzas, PhD Molecular and cellular biology of the skeletal system
Ingrid H. Sarelius, PhD Vascular cell communication and signaling
Edward M. Schwarz, PhD Pro-inflammatory cytokine signal transduction and novel drug and gene therapies for Rheumatoid Arthritis.
Richard E. Waugh, PhD  Cell adhesion, mechanical and thermodynamic properties of biological membranes; cellular mechanics and function of cytoskeletal proteins
David Wu, PhD Biochemical engineering, fermentation, biocatalysis, bone marrow tissue engineering, molecular biology